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. 2005 Feb 28;92(4):651-4.
doi: 10.1038/sj.bjc.6602419.

The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

K Canna  1 , P A McArdle, D C McMillan, A-M McNicol, G W Smith, R F McKee, C S McArdle
Affiliations

The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

K Canna et al. Br J Cancer. .

Abstract

There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer. In all, 147 patients undergoing potentially curative resection for colorectal cancer were studied. Circulating concentrations of C-reactive protein were measured prior to surgery. CD4+ and CD8+ T-lymphocyte infiltration of the tumour was assessed using immunohistochemistry and a point counting technique. When patients were grouped according to the percentage tumour volume of CD4+ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics. However, there was an inverse relationship between percentage tumour CD4+ T-lymphocytes and C-reactive protein (P<0.01). On univariate analysis, both C-reactive protein concentrations (P<0.001) and percentage tumour volume of CD4+ (P<0.05) T-lymphocytes were associated with cancer-specific survival. The results of the present study show that low tumour CD4+ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and both predict poor cancer-specific survival.

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Figures

Figure 1
Figure 1
Relationship between percentage tumour CD4+ T-lymphocyte infiltration and preoperative C-reactive protein in patients undergoing potentially curative resection for colorectal cancer.
Figure 2
Figure 2
Relationship between tumour CD4+ T-lymphocyte infiltration (tertiles decreasing from top to bottom) and cancer-specific survival in patients undergoing potentially curative resection for colorectal cancer.
Figure 3
Figure 3
Relationship between preoperative C-reactive protein (⩽10/>10 mg l−1 from top to bottom) and cancer-specific survival in patients undergoing potentially curative resection for colorectal cancer.
See this image and copyright information in PMC

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