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. 2005 Mar 4;346(4):1083-93.
doi: 10.1016/j.jmb.2004.12.039. Epub 2005 Jan 20.

The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex

Joseph W Arndt  1 , Jenny Gu, Lukasz Jaroszewski, Robert Schwarzenbacher, Michael A Hanson, Frank J Lebeda, Raymond C Stevens
Affiliations

The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex

Joseph W Arndt et al. J Mol Biol. .

Abstract

The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold.

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