Review
doi: 10.1055/s-2005-861030.
A hypothetical index of hypothalamic-pituitary-adrenal (HPA) axis function
Affiliations
- PMID: 15702430
- DOI: 10.1055/s-2005-861030
Item in Clipboard
Review
A hypothetical index of hypothalamic-pituitary-adrenal (HPA) axis function
Horm Metab Res.
2005 Jan.
Abstract
The short ACTH stimulation test (SST) is commonly used by clinicians to determine the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in cases of suspected adrenal insufficiency. Concern has arisen for under-diagnosis of central hypocortisolism using the standard dose (250 mcg) SST with the recent introduction of low-dose (1 mcg) SST as a potentially more sensitive test for central hypocortisolism. Amidst this uncertainty, I will present a novel index hypothesized to extend the sensitivity of the standard dose SST as an adjunctive diagnostic tool for any level of hypocortisolism.
Similar articles
-
Low-dose (1 microgram) adrenocorticotrophin (ACTH) stimulation as a screening test for impaired hypothalamo-pituitary-adrenal axis function: sensitivity, specificity and accuracy in comparison with the high-dose (250 microgram) test.Clin Endocrinol (Oxf). 2000 May;52(5):633-40. doi: 10.1046/j.1365-2265.2000.00984.x. Clin Endocrinol (Oxf). 2000. PMID: 10792344
-
Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests.Eur J Endocrinol. 2005 May;152(5):735-41. doi: 10.1530/eje.1.01911. Eur J Endocrinol. 2005. PMID: 15879359
-
The assessment of the hypothalamo-pituitary-adrenal axis in pituitary disease: are there short cuts?J Endocrinol Invest. 2003;26(7 Suppl):25-30. J Endocrinol Invest. 2003. PMID: 14604063 Review.
-
Comparison of low dose and standard dose adrenocorticotropin stimulation tests in healthy Nigerians.Afr J Med Med Sci. 2010 Jun;39(2):113-8. Afr J Med Med Sci. 2010. PMID: 21117407 Clinical Trial.
-
The diagnosis and investigation of adrenal insufficiency in adults.Ann Clin Biochem. 2009 Sep;46(Pt 5):351-67. doi: 10.1258/acb.2009.009101. Epub 2009 Aug 12. Ann Clin Biochem. 2009. PMID: 19675057 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
