Review
doi: 10.1089/hum.2005.16.1.
Helper-dependent adenoviral vectors for gene therapy
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- PMID: 15703484
- DOI: 10.1089/hum.2005.16.1
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Review
Helper-dependent adenoviral vectors for gene therapy
Hum Gene Ther.
2005 Jan.
Abstract
Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity.
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