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Review
. 2005 Mar;113(8):409-17.
doi: 10.1007/s00412-005-0331-y. Epub 2005 Feb 10.

Rephrasing anaphase: separase FEARs shugoshin

Olaf Stemmann  1 , Dominik Boos, Ingo H Gorr
Affiliations
Review

Rephrasing anaphase: separase FEARs shugoshin

Olaf Stemmann et al. Chromosoma. 2005 Mar.

Abstract

Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent linkage of sister chromatids.

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