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. 2005 Feb;36(1-2):25-34.
doi: 10.1007/s10735-004-2912-0.

Endothelin-1 and endothelin receptors in the basilar artery of the capybara

Andrzej Loesch  1 , Barbara Gajkowska, Michael R Dashwood, Emerson T Fioretto, Karina M Gagliardo, Ana R De Lima, Antonio A C M Ribeiro
Affiliations

Endothelin-1 and endothelin receptors in the basilar artery of the capybara

Andrzej Loesch et al. J Mol Histol. 2005 Feb.

Abstract

Little is known about cerebral vasculature of capybara, which seems may serve as a natural model of studying changes in cerebral circulation due to internal carotid artery atrophy at animal sexual maturation. This is the first study of the light- and electron-immunocytochemical localisation of endothelin-1 (ET-1) and ETA and ETB endothelin receptors in the basilar artery of capybaras (6 to 12-month-old females and males) using an ExtrAvidin detection method. All animals examined showed similar patterns of immunoreactivity. Immunoreactivity for ET-1 was detected in the endothelium and adventitial fibroblasts, whilst immunoreactivity for ETA and ETB receptors was present in the endothelium, vascular smooth muscle, perivascular nerves and fibroblasts. In endothelial cells immunoreactivity to ET-1 was pronounced in the cytoplasm or on the granular endoplasmic reticulum. Similar patterns of immunolabelling were observed for ETA and ETB receptors, though cytoplasmic location of clusters of immunoprecipitate seems dominant. These results suggest that the endothelin system is present throughout the wall of the basilar artery of capybara.

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References

    1. J Anat. 1998 Apr;192 ( Pt 3):435-7 - PubMed
    1. Anat Histol Embryol. 2004 Apr;33(2):81-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7634-8 - PubMed
    1. J Exp Med. 1990 Dec 1;172(6):1741-8 - PubMed
    1. Int J Dev Neurosci. 2000 Dec;18(8):727-34 - PubMed

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