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. 2005 Jan;11(1):22-9.
doi: 10.3201/eid1101.040001.

Multidrug-resistant Acinetobacter baumannii

Aharon Abbo  1 , Shiri Navon-Venezia, Orly Hammer-Muntz, Tami Krichali, Yardena Siegman-Igra, Yehuda Carmeli
Affiliations

Multidrug-resistant Acinetobacter baumannii

Aharon Abbo et al. Emerg Infect Dis. 2005 Jan.

Abstract

To understand the epidemiology of multidrug-resistant (MDR) Acinetobacter baumannii and define individual risk factors for multidrug resistance, we used epidemiologic methods, performed organism typing by pulsed-field gel electrophoresis (PFGE), and conducted a matched case-control retrospective study. We investigated 118 patients, on 27 wards in Israel, in whom MDR A. baumannii was isolated from clinical cultures. Each case-patient had a control without MDR A. baumannii and was matched for hospital length of stay, ward, and calendar time. The epidemiologic investigation found small clusters of up to 6 patients each with no common identified source. Ten different PFGE clones were found, of which 2 dominated. The PFGE pattern differed within temporospatial clusters, and antimicrobial drug susceptibility patterns varied within and between clones. Multivariate analysis identified the following significant risk factors: male sex, cardiovascular disease, having undergone mechanical ventilation, and having been treated with antimicrobial drugs (particularly metronidazole). Penicillins were protective. The complex epidemiology may explain why the emergence of MDR A. baumannii is difficult to control.

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Figures

Figure 1
Figure 1
Distribution of case-patients according to ward.
Figure 2
Figure 2
Monthly case distribution
Figure 3
Figure 3
A typical pulsed-field gel electrophoresis analysis of selected isolates of A. baumannii restricted with ApaI. Lane 1 shows λ ladder used as molecular size marker. Lanes 11–13 are of strains not included in the trial. The gel shows 6 different clones of A. baumannii: 5 isolates belong to clone A and that 2 belong to clone B (the two dominant clones). Single isolates belonging to clones C, D, E, and F can be seen.
See this image and copyright information in PMC

References

    1. Manikal VM, Landman D, Saurina G, Oydna E, Lal H, Quale J. Endemic carbapenem-resistant Acinetobacter species in Brooklyn, New York: citywide prevalence, interinstitutional spread, and relation to antibiotic usage. Clin Infect Dis. 2000;31:101–6. 10.1086/313902 - DOI - PubMed
    1. El Shafie SS, Alishaq M, Leni Garcia M. Investigation of an outbreak of multidrug-resistant Acinetobacter baumannii in trauma intensive care unit. J Hosp Infect. 2004;56:101–5. 10.1016/j.jhin.2003.09.024 - DOI - PubMed
    1. Corbella X, Montero A, Pujol M, Dominguez MA, Ayats J, Argerich MJ. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol. 2000;38:4086–95. - PMC - PubMed
    1. Gales AC, Jones RN, Forward KR, Linares J, Sader SH, Verhoef J. Emerging importance of multidrug-resistant Acinetobacter species and Stentrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features and trends in the SENTRY Antimicrobial Surveillance Program (1997–1999). Clin Infect Dis. 2001;32(Suppl 2):104–13. 10.1086/320183 - DOI - PubMed
    1. Go ES, Urban C, Burns J, Kreiswirth B, Eisner W, Mariano N, et al. Clinical and molecular epidemiology of Acinetobacter infections sensitive only to polymyxin B and sulbactam. Lancet North Am Ed. 1994;344:1329–32. - PubMed

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