Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages

Abstract

Objective: To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples.

Design: Prospective cohort study.

Setting: Tertiary university referral center.

Patient(s): Women (n = 49) with recurrent idiopathic miscarriages.

Intervention(s): In vitro fertilization with preimplantation genetic diagnosis for aneuploidy screening.

Main outcome measure(s): Ongoing pregnancy rate (PR) and aneuploidy rate.

Result(s): The aneuploidy rate was, respectively, 43.85% and 66.95% in the younger and older group. The ongoing PR per cycle was 25.71% in the younger and 2.94% in the older patients.

Conclusion(s): There is no therapeutic evidence to prescribe IVF with or without preimplantation genetic diagnosis for aneuploidy screening for this heterogeneous group of patients.