Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Mar;55(3):283-8.
doi: 10.1093/jac/dkh546. Epub 2005 Feb 10.

Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections

Judith N Steenbergen  1 , Jeff Alder, Grace M Thorne, Francis P Tally
Affiliations
Review

Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections

Judith N Steenbergen et al. J Antimicrob Chemother. 2005 Mar.

Abstract

Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic lipopeptide with activity against most Gram-positive pathogens, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus, is a newly US-FDA approved antimicrobial for complicated skin and skin structure infections (cSSSI). Daptomycin has a unique mechanism of action that results in destruction of the membrane potential. The rapid bactericidal activity of daptomycin makes it an attractive antibiotic for serious Gram-positive infections.

PubMed Disclaimer

MeSH terms