Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Apr 8;308(5719):248-51.
doi: 10.1126/science.1105677. Epub 2005 Feb 10.

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

Taishin Akiyama  1 , Shiori Maeda, Sayaka Yamane, Kaori Ogino, Michiyuki Kasai, Fumiko Kajiura, Mitsuru Matsumoto, Jun-ichiro Inoue
Affiliations
Free article

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

Taishin Akiyama et al. Science. .
Free article

Abstract

The microenvironments of the thymus are generated by thymic epithelial cells (TECs) and are essential for inducing immune self-tolerance or developing T cells. However, the molecular mechanisms that underlie the differentiation of TECs and thymic compartmentalization are not fully understood. Here we show that deficiency in the tumor necrosis factor receptor-associated factor (TRAF) 6 results in disorganized distribution of medullary TECs (mTECs) and the absence of mature mTECs. Engraftment of thymic stroma of TRAF6(-/-) embryos into athymic nude mice induced autoimmunity. Thus, TRAF6 directs the development of thymic stroma and represents a critical point of regulation for self-tolerance and autoimmunity.

PubMed Disclaimer

Publication types