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. 2004;15(2):276-86.

Systematic DNA-binding domain classification of transcription factors

Philip Stegmaier  1 , Alexander E Kel, Edgar Wingender
Affiliations
  • PMID: 15706513

Systematic DNA-binding domain classification of transcription factors

Philip Stegmaier et al. Genome Inform. 2004.

Abstract

Based on the manual annotation of transcription factors stored in the TRANSFAC database, we developed a library of hidden Markov models (HMM) to represent their DNA-binding domains and used it for a comprehensive classification. The models constructed were applied on the UniProt/Swiss-Prot database, leading to a systematic classification of further DNA-binding protein entries. The HMM library obtained can be used to classify any newly discovered transcription factor according to its DNA-binding domain and, thus, to generate hypotheses about its DNA-binding specificity.

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