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. 2005 Mar 1;43(3):367-72.
doi: 10.1016/j.femsim.2004.09.002.

A study on the bacterial photo-toxicity of phenothiazinium based photosensitisers

Zia Sayed  1 , Frederick Harris, David A Phoenix
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Free article

A study on the bacterial photo-toxicity of phenothiazinium based photosensitisers

Zia Sayed et al. FEMS Immunol Med Microbiol. .
Free article

Abstract

"Comet assay" showed light activated (3.15 Jcm-2 over 30 min) phenothiazinium based photosensitisers (PhBPs) to induce photo-damage of Staphylococcus aureus DNA, as indicated by DNA "tails" between 80 and 120 microm. In general, PhBPs exhibited significant singlet oxygen yields (Phi(DeltaPhBP)>0.7), suggesting the use of type II mechanisms of photo-oxidation. However, the photodynamic action of PhBPs on DNA showed generally insignificant production of 7,8-dihydro-8-oxo-2'-deoxyguanosine, normally a major product of type II DNA photo-oxidation. These combined results show DNA to be a major site of action of PhBPs and suggest that this action may involve type II attack on a nucleoside(s) other than guanosine.

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