Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Feb 23;37(2):389-93.
doi: 10.1016/j.jpba.2004.10.022.

Protonation equilibrium and lipophilicity of moxifloxacin

Marie-Hélène Langlois  1 , Martine Montagut, Jean-Pierre Dubost, Jean Grellet, Marie-Claude Saux
Affiliations

Protonation equilibrium and lipophilicity of moxifloxacin

Marie-Hélène Langlois et al. J Pharm Biomed Anal. .

Abstract

This study was performed to characterise the protonation equilibrium at the molecular level and pH-dependent lipophilicity of moxifloxacin. After determining macro- and micro-constants, distribution features of four microspecies in aqueous phase were assessed. The apparent partition coefficient versus pH profile of moxifloxacin showed a parabolic curve in n-octanol/buffer system which reached near pI. The true partition coefficient was calculated from the log P(app) and microconstants values.

PubMed Disclaimer