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Review
. 2005 Mar;64 Suppl 2(Suppl 2):ii9-13.
doi: 10.1136/ard.2004.033654.

Seronegative spondyloarthropathies: to lump or split?

P Nash  1 , P J Mease, J Braun, D van der Heijde
Affiliations
Review

Seronegative spondyloarthropathies: to lump or split?

P Nash et al. Ann Rheum Dis. 2005 Mar.

Abstract

The advent of novel biological therapies for the treatment of rheumatic disease has renewed interest in the seronegative spondyloarthropathies (SpAs). International efforts are redefining disease classification and measures of disease activity, outcome, metrology, and imaging. However, opinion is divided between those who propose that the SpA group represents the same disease with variable expression (the "lumpers") and those who consider these to be separate diseases with shared clinical features (the "splitters"). This review presents the evidence for both approaches.

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References

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