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Review
. 2005 Jan-Feb;14(1):28-36.
doi: 10.1016/j.carpath.2004.11.005.

The role of transforming growth factor beta1 in the vascular system

Jonathan Ghosh  1 , Michael O Murphy, Neill Turner, Nadeem Khwaja, Anastassi Halka, Cay M Kielty, Michael G Walker
Affiliations
Review

The role of transforming growth factor beta1 in the vascular system

Jonathan Ghosh et al. Cardiovasc Pathol. 2005 Jan-Feb.

Abstract

The transforming growth factor beta (TGFbeta) family of cytokines exert pleiotropic effects upon a wide variety of cell types. TGFbeta1 has been demonstrated to be of fundamental importance in the development, physiology and pathology of the vascular system. As the role of TGFbeta1 in these processes becomes clearer, influencing its activity for therapeutic benefit is now beginning to be investigated. This review presents an overview of the role of TGFbeta1 in the vasculature. The cellular and extracellular biology of the TGFbeta family is first addressed, followed by an overview of the function of TGFbeta1 during vascular development, atherogenesis, hypertension, and vessel injury.

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