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. 2005 Feb 14;579(5):1191-6.
doi: 10.1016/j.febslet.2004.12.090. Epub 2005 Jan 19.

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

Marian E Durkin  1 , Miriam R Avner, Chang-Goo Huh, Bao-Zhu Yuan, Snorri S Thorgeirsson, Nicholas C Popescu
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Free article

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

Marian E Durkin et al. FEBS Lett. .
Free article

Abstract

DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions.

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