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Comment
. 2005 Feb 22;102(8):2679-80.
doi: 10.1073/pnas.0500213102. Epub 2005 Feb 14.

Endocytosis of membrane receptors: two pathways are better than one

Rubén Claudio Aguilar  1 , Beverly Wendland
Affiliations
Comment

Endocytosis of membrane receptors: two pathways are better than one

Rubén Claudio Aguilar et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
CIE and CDE pathways. High [EGF] induces Ub modification of the EGFR, recognition by the UIMs of epsin and Eps15/R, and subsequent degradation. Low [EGF] promotes recognition by the classic AP2 cargo adaptor and internalization via clathrin-coated vesicles, leading to efficient signal transduction. Epsin and Eps15/R bind to each other and to other proteins to assist in the process. Binding motifs are color coded; ENTH, epsin N-terminal homology; Yxx0, tyrosine-based sorting signal.
Fig. 2.
Fig. 2.
Epsin as a switch that senses or is regulated by receptor ubiquitylation status.
See this image and copyright information in PMC

Comment on

References

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