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. 2005;23(3):190-5.
doi: 10.1159/000083940. Epub 2005 Feb 10.

Endothelin-1 levels and conduit artery mechanical properties in end-stage renal disease

Ruben Dammers  1 , Arnold P G Hoeks, Jan H M Tordoir, Rob J Th J Welten, Karly Hamulyák, Jeroen P Kooman, Peter J E H M Kitslaar
Affiliations

Endothelin-1 levels and conduit artery mechanical properties in end-stage renal disease

Ruben Dammers et al. Blood Purif. 2005.

Abstract

Background: Endothelial cell (EC) dysfunction markers are increased in end-stage renal disease (ESRD). The present study focused on the relationship between EC markers, conduit artery wall mechanics and hemodynamics in ESRD.

Methods: In 29 ESRD patients and 16 controls, brachial artery diameter, distension, and wall thickness was measured and circumferential wall stress (CWS) calculated. Shear stress was determined with a shear rate-estimating system. Furthermore, von Willebrand factor antigen (vWF) and endothelin-1 (ET-1) levels were measured.

Results: vWF (p = 0.002) and ET-1 (p < 0.001) were higher in ESRD patients and vWF was related to ET-1 (r = 0.70, p = 0.005). Peak (p = 0.001) and mean shear stress (p = 0.003) were significantly lower in ESRD patients, and ET-1 showed an inverse log linear relation with both (peak: r = -0.59, p = 0.016; mean: r = -0.64, p = 0.007). Also, ET-1 was log linearly related to CWS (r = 0.58, p = 0.014).

Conclusion: These results indicate that, in ESRD, conduit artery shear stress is lower, which might be secondary to an increased peripheral vascular resistance caused by higher ET-1 levels.

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