doi: 10.1021/ja043920g.
Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers
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- PMID: 15713063
- DOI: 10.1021/ja043920g
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Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers
J Am Chem Soc.
.
Abstract
The synthesis of a new zwitterionic diblock copolymer poly(l-glutamic acid)-b-poly(l-lysine) (PGA-b-PLys) is described, and its self-assembly into schizophrenic vesicles that can reversibly be produced in moderate acidic or basic aqueous solutions is reported. These pH-sensitive nanoparticles are expected to be very promising candidates in macromolecular nanobiotechnologies.
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