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. 2005 Mar 1;15(5):1501-4.
doi: 10.1016/j.bmcl.2004.12.083.

Glucokinase-activating ureas

Arlindo L Castelhano  1 , Hanqing Dong, Matthew C T Fyfe, Lisa S Gardner, Yukari Kamikozawa, Satomi Kurabayashi, Masao Nawano, Rikiya Ohashi, Martin J Procter, Li Qiu, Chrystelle M Rasamison, Karen L Schofield, Vilas K Shah, Kiichiro Ueta, Geoffrey M Williams, David Witter, Kosuke Yasuda
Affiliations

Glucokinase-activating ureas

Arlindo L Castelhano et al. Bioorg Med Chem Lett. .

Abstract

The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.

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