Review
doi: 10.1038/nrg1527.
Conserved non-genic sequences - an unexpected feature of mammalian genomes
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- PMID: 15716910
- DOI: 10.1038/nrg1527
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Review
Conserved non-genic sequences - an unexpected feature of mammalian genomes
Nat Rev Genet.
2005 Feb.
Abstract
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
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