Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Feb;6(2):151-7.
doi: 10.1038/nrg1527.

Conserved non-genic sequences - an unexpected feature of mammalian genomes

Emmanouil T Dermitzakis  1 , Alexandre Reymond, Stylianos E Antonarakis
Affiliations
Review

Conserved non-genic sequences - an unexpected feature of mammalian genomes

Emmanouil T Dermitzakis et al. Nat Rev Genet. 2005 Feb.

Abstract

Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources