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. 2005 Feb 18;19(3):341-2.

The efavirenz-induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism

Carlos Alonso-Villaverde  1 , Blai Coll, Federico Gómez, Sandra Parra, Jordi Camps, Jorge Joven, Lluis Masana
Affiliations
  • PMID: 15718846

The efavirenz-induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism

Carlos Alonso-Villaverde et al. AIDS. .

Abstract

Efavirenz treatment has been associated with increases in HDL-cholesterol concentrations, and the circulating levels of the drug have been related to the multidrug resistance gene 1 (MDR-1) C3435T polymorphism. The changes in the measured lipid parameters were evaluated in 59 HIV-infected patients initiating efavirenz-based treatment at baseline and at 12 months of follow-up. Efavirenz treatment increased HDL-cholesterol. The changes in concentrations appeared to be influenced by the MDR-1 gene polymorphism, in which CC > CT > TT.

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