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Review
. 2005 Feb;5(2):197-205.
doi: 10.2174/1389557053402701.

The impact of lipophilicity in drug research: a case report on beta-blockers

Raimund Mannhold  1
Affiliations
Review

The impact of lipophilicity in drug research: a case report on beta-blockers

Raimund Mannhold. Mini Rev Med Chem. 2005 Feb.

Abstract

The key importance of lipophilicity in bio-studies is discussed for beta-blockers. Examples of their lipophilicity-dependent pharmacological properties including pharmacokinetic, pharmacodynamic and clinical aspects are reviewed. Comprehensive lipophilicity compilations of beta-blockers are lacking so far. LogP calculations with 10 programs for 30 clinically relevant beta-blockers are presented for the first time in this review.

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