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. 1992 May;88(2):237-42.
doi: 10.1111/j.1365-2249.1992.tb03067.x.

Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC

F Hentges  1 , A Hoffmann, F Oliveira de Araujo, R Hemmer
Affiliations

Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC

F Hentges et al. Clin Exp Immunol. 1992 May.

Abstract

The length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV-1-infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.

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