Review
doi: 10.1007/s00018-004-4297-y.
The role of insulin and IGF-1 signaling in longevity
Affiliations
- PMID: 15723168
- PMCID: PMC11924452
- DOI: 10.1007/s00018-004-4297-y
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Review
The role of insulin and IGF-1 signaling in longevity
Cell Mol Life Sci.
2005 Feb.
Abstract
There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.
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