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Review
. 2005 Feb 22;15(4):R122-4.
doi: 10.1016/j.cub.2005.02.008.

Checkpoint signalling: Mad2 conformers and signal propagation

Kevin G Hardwick  1
Affiliations
Free article
Review

Checkpoint signalling: Mad2 conformers and signal propagation

Kevin G Hardwick. Curr Biol. .
Free article

Abstract

The spindle checkpoint protein Mad2 has a tendency to form multimers and adopts at least two structural conformations. New work highlights the importance of the Mad2-Mad2 interaction, and suggests how spindle checkpoint signals are propagated away from kinetochores.

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