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. 2005 Mar;78(3):240-2.
doi: 10.1002/ajh.20292.

Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70

Adeboye H Adewoye  1 , Elizabeth S Klings, Harrison W Farber, Elizabeth Palaima, Maria A Bausero, Lillian McMahon, Adam Odhiambo, Safaya Surinder, Mark Yoder, Martin H Steinberg, Alexzander Asea
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Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70

Adeboye H Adewoye et al. Am J Hematol. 2005 Mar.

Abstract

Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.

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References

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