Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Mar 15;13(6):2305-12.
doi: 10.1016/j.bmc.2004.12.042.

Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase

Søren Ebdrup  1 , Poul Jacobsen, Anupma Dhanda Farrington, Per Vedsø
Affiliations

Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase

Søren Ebdrup et al. Bioorg Med Chem. .

Abstract

A range of aryl and heteroaryl boronic acids were tested for their in vitro hormone-sensitive lipase inhibitory properties. (2-Benzyloxy-5-fluorophenyl)boronic acid, (2-benzyloxy-5-chlorophenyl)boronic acid and 5-bromothiophene-2-boronic acid were found to be the most potent HSL inhibitors with IC(50) values of 140, 17 and 350 nM, respectively.

PubMed Disclaimer

MeSH terms

LinkOut - more resources