Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Mar;49(3):1220-1.
doi: 10.1128/AAC.49.3.1220-1221.2005.

Experimental bacteriophage protection against Staphylococcus aureus abscesses in a rabbit model

Quintin F Wills  1 , Claire Kerrigan, James S Soothill
Affiliations

Experimental bacteriophage protection against Staphylococcus aureus abscesses in a rabbit model

Quintin F Wills et al. Antimicrob Agents Chemother. 2005 Mar.

Abstract

In a rabbit model of wound infection caused by Staphylococcus aureus, 2 x 10(9) PFU of staphylococcal phage prevented abscess formation in rabbits when it was injected simultaneously with S. aureus (8 x 10(7) CFU) into the same subcutaneous site. Phage multiplied in the tissues. Phages might be a valuable prophylaxis against staphylococcal infection.

PubMed Disclaimer

References

    1. Adams, M. H. 1959. Bacteriophages, p. 447-448. Interscience Publishers, Inc., New York, N.Y.
    1. Barrow, P., M. Lovell, and A. Berchieri, Jr. 1998. Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves. Clin. Diagn. Lab. Immunol. 5:294-298. - PMC - PubMed
    1. Biswas, B., S. Adhya, P. Washart, B. Paul, A. N. Trostel, B. Powell, R. Carlton, and C. R. Merril. 2002. Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium. Infect. Immun. 70:204-210. - PMC - PubMed
    1. Cerveny, K. E., A. De Paola, D. H. Duckworth, and P. Gulig. 2002. Phage therapy of local and systemic disease caused by Vibrio vulnificus in iron-dextran-treated mice. Infect. Immun. 70:6251-6262. - PMC - PubMed
    1. Dubos, R. J., J. H. Straus, and C. Pierce. 1943. The multiplication of bacteriophage in vivo and its protective effect against an experimental infection with Shigella dysenteriae. J. Exp. Med. 78:161-168. - PMC - PubMed

MeSH terms