Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Apr;30(4):935-41.
doi: 10.1128/jcm.30.4.935-941.1992.

Genetic similarity and maintenance of Candida albicans strains from a group of AIDS patients, demonstrated by DNA fingerprinting

J Schmid  1 , F C Odds, M J Wiselka, K G Nicholson, D R Soll
Affiliations
Comparative Study

Genetic similarity and maintenance of Candida albicans strains from a group of AIDS patients, demonstrated by DNA fingerprinting

J Schmid et al. J Clin Microbiol. 1992 Apr.

Abstract

By using the computer-assisted Dendron system to analyze the patterns of Southern blots probed with the repetitive sequence Ca3, we have compared oral isolates of Candida spp. from a group of 11 nonhospitalized patients with AIDS suffering from recurrent episodes of oral thrush in Leicester, England, with oral isolates from a group of control individuals. Genetic diversity among the AIDS strains was significantly reduced compared with that of control strains. In addition, the same strains persisted through recurrent infections in patients with AIDS. Although AIDS strains were genetically less diverse than either control strains or oral commensal strains analyzed in previous studies, the majority did not form a genetically distinct group. The results of this study suggest that in the majority of patients with AIDS in this group from Leicester, original commensal strains were replaced, replacement occurred early in the manifestation of AIDS, and replacement occurred only once.

PubMed Disclaimer

References

    1. J Clin Microbiol. 1991 Aug;29(8):1702-10 - PubMed
    1. J Bacteriol. 1991 Jan;173(2):842-50 - PubMed
    1. Gastroenterol Clin North Am. 1988 Sep;17(3):535-43 - PubMed
    1. J Clin Microbiol. 1987 Sep;25(9):1611-22 - PubMed
    1. J Clin Microbiol. 1987 Apr;25(4):675-9 - PubMed

Publication types

MeSH terms