Neonatal enucleation induces correlated modification in sensory responsive areas and pial angioarchitecture of the parietal and occipital cortex of albino rats

Abstract

This study was carried out to investigate whether correlations existing in normal adult rats (Ambach et al., '86) between functional characteristics of neocortical areas and their pial angioarchitecture can be correspondingly modified under pathological conditions. The right eyes of albino rats were enucleated on the 1st, 8th, 15th and 30th day after birth, respectively. At the age of 3 to 4 months, the responsiveness of the parieto-occipital cortex to sensory stimuli was studied in enucleated animals and age matched controls. After the mapping of visually and somatosensorily evoked potentials, the vascular system was filled with dye. Monocular enucleation at birth induced bilateral modifications in sensory responsiveness and corresponding changes in pial angioarchitecture, especially in the venous drainage fields. In comparison with the controls, a considerable expansion was observed in the overlapping zone between visually and somatosensorily responsive areas. In contrast, borders of the visual cortex toward the auditory and retrosplenial areas were essentially stable. Corresponding changes were found in the pial distribution patterns of cerebral veins but not of arteries. The major effect of neonatal enucleation on angioarchitecture was a change in the subdivision of the parieto-occipital veins drainage fields. This was due to a significant enlargement of the anterior accessory occipital (O3) vein, which compressed the drainage fields of the parietal and occipital veins and completely separated them from one another. The results suggest that during ontogenesis: (1) alterations in the formation of sensory input may interfere with neocortical angiogenesis, especially the structuring of veins, (2) after monocular enucleation this influence is prominent in parietal and occipital cerebral veins, and (3) these angiogenetic processes are vulnerable only during the perinatal and early postnatal period.