Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2005 Mar;57(3):453-6.
doi: 10.1002/ana.20401.

Clinical and positron emission tomography of Parkinson's disease caused by LRRK2

Dena G Hernandez  1 , Coro Paisán-Ruíz, Aideen McInerney-Leo, Shushant Jain, Andreas Meyer-Lindenberg, E Whitney Evans, Karen F Berman, Janel Johnson, Georg Auburger, Alejandro A Schäffer, Grisel J Lopez, Robert L Nussbaum, Andrew B Singleton
Affiliations
Comparative Study

Clinical and positron emission tomography of Parkinson's disease caused by LRRK2

Dena G Hernandez et al. Ann Neurol. 2005 Mar.

Abstract

We have recently identified mutations in a gene leucine-rich repeat kinase-2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patients, including 6-(18)F-fluoro-L-dopa positron emission tomography and discuss the potential implications of this mutation, which alters a conserved residue in a domain required for kinase activation.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources