Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2004 Jan-Mar;173(1):34-7.
doi: 10.1007/BF02914522.

Naltrexone for alcohol-dependent patients

J Ahmadi  1 , M Babaeebeigi, I Maany, J Porter, M Mohagheghzadeh, N Ahmadi, G Dehbozorgi
Affiliations
Clinical Trial

Naltrexone for alcohol-dependent patients

J Ahmadi et al. Ir J Med Sci. 2004 Jan-Mar.

Abstract

Background: Clinical trials have shown that naltrexone 50 mg/day reduces alcohol consumption and relapse rates in alcohol dependents.

Aim: To investigate the efficacy of 50mg/day dose of naltrexone in the maintenance of alcohol-dependent subjects over a 36-week treatment period.

Methods: Subjects were randomised into two equal groups, consisting of 116 male alcohol-dependent patients who met the DSM-IV criteria for alcohol dependence and were seeking treatment. The participants received naltrexone or placebo at a dose of 50 mg/day and were treated in an outpatient clinic, offering a weekly 0.5-hour individual counselling session. Days retained in treatment were measured.

Results: Forty-one participants (35.3%) completed the 36-week study. Completion rates by group were 44.8% for the 50 mg naltrexone group and 25.9% for the placebo group (chi2=4.56, DF=1, 2-sided significance=0.033).

Conclusion: The results support the efficacy and safety of naltrexone for outpatient treatment of alcohol-dependent individuals in Iran.

PubMed Disclaimer

References

    1. Pharmacol Biochem Behav. 1990 Feb;35(2):385-90 - PubMed
    1. Am J Psychiatry. 1995 Apr;152(4):613-5 - PubMed
    1. Life Sci. 1986 Mar 3;38(9):841-7 - PubMed
    1. Am J Psychiatry. 1994 Oct;151(10):1463-7 - PubMed
    1. Alcohol Clin Exp Res. 1993 Jun;17(3):631-6 - PubMed

Publication types

LinkOut - more resources