Making a new turn in matrix metalloprotease inhibition
- PMID: 15734640
- DOI: 10.1016/j.chembiol.2005.01.008
Making a new turn in matrix metalloprotease inhibition
Abstract
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.
Comment on
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Structural basis for the highly selective inhibition of MMP-13.Chem Biol. 2005 Feb;12(2):181-9. doi: 10.1016/j.chembiol.2004.11.014. Chem Biol. 2005. PMID: 15734645
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