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Review
. 2005 Mar;124(3):481-92.
doi: 10.1111/j.0022-202X.2005.23627.x.

Transglutaminase function in epidermis

Richard L Eckert  1 , Michael T Sturniolo, Ann-Marie Broome, Monica Ruse, Ellen A Rorke
Affiliations
Free article
Review

Transglutaminase function in epidermis

Richard L Eckert et al. J Invest Dermatol. 2005 Mar.
Free article

Abstract

Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.

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