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Case Reports
. 2005 Feb 28;165(4):464-5.
doi: 10.1001/archinte.165.4.464.

Bortezomib-induced severe hepatitis in multiple myeloma: a case report

Laura Rosiñol  1 , Silvia Montoto, Maria Teresa Cibeira, Joan Bladé
Affiliations
Case Reports

Bortezomib-induced severe hepatitis in multiple myeloma: a case report

Laura Rosiñol et al. Arch Intern Med. .

Abstract

Bortezomib is a novel proteasome inhibitor with significant antimyeloma activity. Its toxicity is manageable, and the most frequent adverse effects mainly consist of gastrointestinal symptoms, peripheral neuropathy, neuropatic pain, and thrombocytopenia. Severe liver toxicity has not been previously recognized. A patient with relapsed multiple myeloma who developed bortezomib-induced severe recurrent hepatitis is described. The importance of recognizing this rare potential toxicity is highlighted in order to discontinue this agent if liver adverse reaction is suspected.

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