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. 2005 Mar 1;172(5):625-6.
doi: 10.1503/cmaj.1041393.

Administering antihypertensive drugs after acute ischemic stroke: timing is everything

Andrea Semplicini  1 , Lorenzo Calò
Affiliations

Administering antihypertensive drugs after acute ischemic stroke: timing is everything

Andrea Semplicini et al. CMAJ. .
No abstract available

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Figures

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Fig. 1: Autoregulation of cerebral blood flow in a normal brain and in the ischemic penumbra (the tissues surrounding the ischemic core after a stroke). In the normal brain, cerebral blood flow is kept at 50 mL/100 g per minute, despite continuous fluctuations of mean blood pressure between 70 and 120 mm Hg (continuous line). Any increase in pressure leads to vasoconstriction and any decrease to vasodilation, which prevents the risk of cerebral hyper- and hypoperfusion, respectively. Above and below the limits of cerebral blood flow autoregulation, cerebral perfusion passively follows the perfusion pressure. In the ischemic penumbra, tissue perfusion follows perfusion pressure (dashed line): any fall in blood pressure may precipitate ischemia, while an increase in blood pressure may cause edema and hemorrhagic transformation.
See this image and copyright information in PMC

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