Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity
- PMID: 15738991
- DOI: 10.1039/b416418k
Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity
Abstract
Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation. The photoprocess occurs with identical efficiency in N2-saturated and air-equilibrated media, indicating that this photosensitization modality does not require the presence of oxygen.
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