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. 2005 Mar;4(3):251-3.
doi: 10.1039/b416418k. Epub 2005 Feb 14.

Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity

Monica Camerin  1 , Michael A J Rodgers, Malcolm E Kenney, Giulio Jori
Affiliations

Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity

Monica Camerin et al. Photochem Photobiol Sci. 2005 Mar.

Abstract

Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation. The photoprocess occurs with identical efficiency in N2-saturated and air-equilibrated media, indicating that this photosensitization modality does not require the presence of oxygen.

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