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Review
. 2005 Mar;6(3):218-9.
doi: 10.1038/sj.embor.7400362.

Actin in transcription. Actin is required for transcription by all three RNA polymerases in the eukaryotic cell nucleus

Neus Visa  1
Affiliations
Review

Actin in transcription. Actin is required for transcription by all three RNA polymerases in the eukaryotic cell nucleus

Neus Visa. EMBO Rep. 2005 Mar.

Abstract

Actin is required for transcription by all three RNA polymerases in the eukaryotic cell nucleus

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Figures

Figure 1
Figure 1
Actin and nuclear myosin 1 in transcription by RNA polymerase I. Actin is directly associated with RNA polymerase I (Pol I), regardless of whether Pol I is engaged in transcription, and nuclear myosin 1 (NM1) interacts with transcription initiation factor TIF-IA. Extracellular mitogens activate signalling cascades that lead to TIF-IA phosphorylation. Pol I is then recruited to the ribosomal DNA promoter through interaction with the phosphorylated TIF-IA, which brings actin and NM1 into close proximity with each other. Actin, but not NM1, remains associated with Pol I during transcription elongation.
See this image and copyright information in PMC

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