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Clinical Trial
. 2005 Feb 21;11(7):1048-51.
doi: 10.3748/wjg.v11.i7.1048.

Response of blood endothelin-1 and nitric oxide activity in duodenal ulcer patients undergoing Helicobacter pylori eradication

Full-Young Chang  1 , Chih-Yen Chen, Ching-Liang Lu, Jiing-Chyuan Luo, Rei-Hwa Lu, Shou-Dong Lee
Affiliations
Clinical Trial

Response of blood endothelin-1 and nitric oxide activity in duodenal ulcer patients undergoing Helicobacter pylori eradication

Full-Young Chang et al. World J Gastroenterol. .

Abstract

Aim: To investigate the effect of Helicobacter pylori eradication on endothelin-1 (ET-1) and nitric oxide (NO) in duodenal ulcer (DU) patients.

Methods: Sixty-six H pylori-infected active DU patients were consecutively enrolled to receive one-week triple therapy (rabeprazole, amoxicillin and metronidazole) and then one-month rabeprazole therapy. They were asked back to determine ulcer and H pylori status using endoscopy one month later. Thirty-seven healthy controls (H pylori +/-: 17/20) were enrolled for comparison. Blood samples were collected in each visit to measure plasma ET-1 and nitrate/nitrite levels using an enzyme immunoassay kit.

Results: Sixty DU patients finished trial per protocol. The ulcer healing and H pylori-eradication rates were 86.7% and 83.3%, respectively. Plasma ET-1 level in DU patients was higher than that of H pylori-negative and positive controls (3.59+/-0.96 vs 0.89+/-0.54 vs 0.3+/-0.2 pg/mL, P<0.01), while nitrate/nitrite levels among them were also significantly different (8.55+/-0.71 vs 5.27+/-0.68 vs 6.39+/-0.92 mumol/L, P<0.05). H pylori eradication diminished ET-1 levels (3.64+/-0.55 vs 2.64+/-0.55 pg/mL, P<0.01) but elevated nitrate/nitrite level (8.16+/-0.84 vs 11.41+/-1.42 mumol/L, P<0.05).

Conclusion: Both plasma ET-1 and nitrate/nitrite levels increase in active DU patients. After an effective H pylori eradication, DU healing is associated with diminished blood ET-1 level and elevated nitrate/nitrite level.

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Figures

Figure 1
Figure 1
Measured plasma endothelin-1 levels and ulcer sizes in 60 patients with active ulcer crater.
Figure 2
Figure 2
Change of plasma ET-1 levels (A) and nitrate/nitrite levels (B) in duodenal ulcer patients before (■) and after (□) H pylori eradication treatment.
See this image and copyright information in PMC

References

    1. Soll AH. Peptic ulcer and its complications. In: Sleisenger & Fordtran's Gastrointestinal and Liver Disease., editor. Feldman M, Scharschmidt BF and Sleisenger MH, eds. 6th ed. Philadelphia: WB Saunders; 1998. p. 620 678.
    1. Cho CH, Koo MW, Garg GP, Ogle CW. Stress-induced gastric ulceration: its aetiology and clinical implications. Scand J Gastroenterol. 1992;27:257–262. - PubMed
    1. Kamada T, Kawano S, Sato N, Fukuda M, Fusamoto H, Abe H. Gastric mucosal blood distribution and its changes in the healing process of gastric ulcer. Gastroenterology. 1983;84:1541–1546. - PubMed
    1. Yanagisawa M. The endothelin system. A new target for therapeutic intervention. Circulation. 1994;89:1320–1322. - PubMed
    1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415. - PubMed

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