doi: 10.1186/1742-4690-2-17.
The discovery of the first human retrovirus: HTLV-1 and HTLV-2
Affiliations
- PMID: 15743526
- PMCID: PMC555587
- DOI: 10.1186/1742-4690-2-17
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The discovery of the first human retrovirus: HTLV-1 and HTLV-2
Retrovirology.
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Abstract
I describe here the history leading up to and including my laboratory's discovery of the first human retrovirus, HTLV-I, and its close relative, HTLV-II. My efforts were inspired by early work showing a retroviral etiology for leukemias in various animals, including non-human primates. My two main approaches were to develop criteria for and methods for detection of viral reverse transcriptase and to identify growth factors that could support the growth of hematopoietic cells. These efforts finally yielded success following the discovery of IL-2 and its use to culture adult T cell lymphoma/leukemia cells.
Comment in
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Retrovirology highlights a quarter century of HTLV-I research.Retrovirology. 2005 Mar 2;2:15. doi: 10.1186/1742-4690-2-15. Retrovirology. 2005. PMID: 15743525 Free PMC article.
References
-
- Gallo RC, Perry S, Breitman TR. The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes. I. Substrate inhibition by thymine and activation by phosphate or arsenate. J Biol Chem. 1967;242:5059–5068. - PubMed
-
- Gallo RC, Breitman TR. The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes. II. Comparison of deoxyribosyl donors. J Biol Chem. 1968;243:4936–4942. - PubMed
-
- Gallo RC, Breitman TR. The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes. III. Inhibition of deoxythymidine phosphorylase by purines. J Biol Chem. 1968;243:4943–4951. - PubMed
-
- Smith RG, Abrell JW, Lewis BJ, Gallo RC. Serological analysis of human deoxyribonucleic acid polymerases. Preparation and properties of antiserum to deoxyribonucleic acid polymerase I from human lymphoid cells. J Biol Chem. 1975;250:1702–1709. - PubMed