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Case Reports
. 2005 Feb 28;46(1):173-6.
doi: 10.3349/ymj.2005.46.1.173.

A case of pulmonary cryptococcosis with non-small cell lung cancer in idiopathic CD4+ T-lymphocytopenia

In-Seon Ahn  1 , Hee-gu Kim, Jeong-Seon Ryu, Lucia Kim, Seung-Min Kwak, Hong-Lyeol Lee, Yong-Hwan Yoon, Jae-Hwa Cho
Affiliations
Case Reports

A case of pulmonary cryptococcosis with non-small cell lung cancer in idiopathic CD4+ T-lymphocytopenia

In-Seon Ahn et al. Yonsei Med J. .

Abstract

Cryptococcus neoformans commonly causes opportunistic infections in immunocompromised patients, especially in patients with AIDS. CD4+ T-lymphocytopenia in AIDS indicates an increased risk of opportunistic infection and a decline in immunological function. Idiopathic CD4 T-lymphocytopenia (ICL) is characterized by depletions in the CD4+ T-cell subsets, without evidence of HIV infection. Immunodeficiency can exist in the absence of laboratory evidence of HIV infection, and T-cell subsets should be evaluated in patients who present with unusual opportunistic infections. We report a case of pulmonary cryptococcosis and lung cancer in a patient with persistently low CD4+ cell counts, without evidence of HIV infection.

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Figures

Fig. 1
Fig. 1
Chest PA showed multiple patch consolidations and thick-walled cavitary lesions, with nodules in both lung fields.
Fig. 2
Fig. 2
Chest CT scan showed multiple patch consolidations, nodules with cavity formations, and severe wall thickening of subsegmental bronchi in both lung fields.
Fig. 3
Fig. 3
Histologic findings were yeast-form fungi, consistent with cryptococci (H&E, × 200).
See this image and copyright information in PMC

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