Review
doi: 10.1182/blood-2004-12-4760.
"You break it, you fix it."
Affiliations
- PMID: 15747400
- DOI: 10.1182/blood-2004-12-4760
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Review
"You break it, you fix it."
Blood.
.
Free article
Abstract
Nonrandom chromosomal translocations are considered to be causal events leading to leukemic transformation. However, the mechanism(s) that cause these translocations are poorly understood. Libura and colleagues report exciting new findings on the mechanism(s) that lead to chromosomal translocation.
Comment on
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Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion.Blood. 2005 Mar 1;105(5):2124-31. doi: 10.1182/blood-2004-07-2683. Epub 2004 Nov 4. Blood. 2005. PMID: 15528316
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