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Review
. 2005 Mar 1;105(5):1847-8.
doi: 10.1182/blood-2004-12-4766.

Soluble urokinase activator receptor (suPAR) in stem cell mobilization

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Free article
Review

Soluble urokinase activator receptor (suPAR) in stem cell mobilization

Elaine Marie Sloand. Blood. .
Free article

Abstract

Selleri et al demonstrate that healthy donors given granulocyte-colony-stimulating factor (G-CSF) have increases in plasma soluble plasminogen activator receptor (suPAR) levels, which in turn induces chemotaxis of CD34 cells. Selleri et al's findings help better define the complicated mechanism of stem cell mobilization by G-CSF and point to a wide role for uPAR in cell surface adhesion and recognition.

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