Soluble urokinase activator receptor (suPAR) in stem cell mobilization
- PMID: 15747404
- DOI: 10.1182/blood-2004-12-4766
Soluble urokinase activator receptor (suPAR) in stem cell mobilization
Abstract
Selleri et al demonstrate that healthy donors given granulocyte-colony-stimulating factor (G-CSF) have increases in plasma soluble plasminogen activator receptor (suPAR) levels, which in turn induces chemotaxis of CD34 cells. Selleri et al's findings help better define the complicated mechanism of stem cell mobilization by G-CSF and point to a wide role for uPAR in cell surface adhesion and recognition.
Comment on
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Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization.Blood. 2005 Mar 1;105(5):2198-205. doi: 10.1182/blood-2004-06-2424. Epub 2004 Oct 19. Blood. 2005. PMID: 15494432
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