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. 2005 Mar;53(3):269-72.
doi: 10.1369/jhc.4B6391.2005.

Fluorescence in situ hybridization and spectral imaging analysis of human oocytes and first polar bodies

Heinz-Ulli G Weier  1 , Jingly F Weier, Maria Oter Renom, Xuezhong Zheng, Pere Colls, Aida Nureddin, Chau D Pham, Lisa W Chu, Catherine Racowsky, Santiago Munné
Affiliations

Fluorescence in situ hybridization and spectral imaging analysis of human oocytes and first polar bodies

Heinz-Ulli G Weier et al. J Histochem Cytochem. 2005 Mar.

Abstract

We investigated the frequencies of abnormalities involving either chromosome 1, 16, 18, or 21 in failed-fertilized human oocytes. Although abnormalities involving chromosome 16 showed an age-dependent increase, results for the other chromosomes did not show statistically significant differences among the three age groups, <35 years, 35-39 years, and >39 years. The scoring of four chromosomes is likely to underestimate the true rate of aneuploid cells. Therefore, for a pilot study investigating a more-comprehensive analysis of oocytes and their corresponding first polar bodies, we developed a novel eight-probe chromosome enumeration scheme using fluorescence in situ hybridization and spectral imaging analysis.

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