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. 2005 Apr;12(4):378-9.
doi: 10.1038/nsmb908. Epub 2005 Mar 6.

The structural basis of blebbistatin inhibition and specificity for myosin II

John S Allingham  1 , Robert Smith, Ivan Rayment
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The structural basis of blebbistatin inhibition and specificity for myosin II

John S Allingham et al. Nat Struct Mol Biol. 2005 Apr.

Abstract

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

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