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. 2005 Mar 8;64(5):902-4.
doi: 10.1212/01.WNL.0000153076.46126.E9.

DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment

K Kantarci  1 , R C Petersen, B F Boeve, D S Knopman, S D Weigand, P C O'Brien, M M Shiung, G E Smith, R J Ivnik, E G Tangalos, C R Jack Jr
Affiliations

DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment

K Kantarci et al. Neurology. .

Abstract

The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.

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Figures

Figure 1
Figure 1
Hippocampal ROI are traced on the coronal FLAIR image (b=0 mm2/sec) (a). These ROI concurrently appear on the ADC (average) map (b). The corresponding coronal T1-weighted image is used to guide the placement of the ROI (c).
Figure 1
Figure 1
Hippocampal ROI are traced on the coronal FLAIR image (b=0 mm2/sec) (a). These ROI concurrently appear on the ADC (average) map (b). The corresponding coronal T1-weighted image is used to guide the placement of the ROI (c).
Figure 1
Figure 1
Hippocampal ROI are traced on the coronal FLAIR image (b=0 mm2/sec) (a). These ROI concurrently appear on the ADC (average) map (b). The corresponding coronal T1-weighted image is used to guide the placement of the ROI (c).
Figure 2
Figure 2
Kaplan-Meier plots of the estimated probability of aMCI patients remaining stable as a function of follow-up time. The plots represent aMCI patients with hippocampal ADC ≤ 888 × 10−6 mm2/s (median hippocampal ADC among aMCIs), and aMCI patients with hippocampal ADC >888 × 10−6 mm2/s.
See this image and copyright information in PMC

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