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. 2005 Mar 8;64(5):912-3.
doi: 10.1212/01.WNL.0000152840.26156.74.

MTX-induced white matter changes are associated with polymorphisms of methionine metabolism

M Linnebank  1 , H Pels, N Kleczar, S Farmand, K Fliessbach, H Urbach, K Orlopp, T Klockgether, I G H Schmidt-Wolf, U Schlegel
Affiliations

MTX-induced white matter changes are associated with polymorphisms of methionine metabolism

M Linnebank et al. Neurology. .

Abstract

Methotrexate (MTX) is a folate antagonist inhibiting nucleic acid and methionine synthesis. Methionine is necessary for CNS myelination. In 42 patients with primary CNS lymphoma (PCNSL) treated with a systemic and intraventricular high-dose MTX-based polychemotherapy, the presence of a risk haplotype defined by polymorphisms influencing methionine metabolism referred a relative risk for CNS white matter changes of 4.7 (p = 0.001). The authors conclude that methionine metabolism influences MTX neurotoxicity.

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