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Review
. 2005 Apr;54(4):556-63.
doi: 10.1136/gut.2004.048181.

Infection, coagulation, and variceal bleeding in cirrhosis

U Thalheimer  1 , C K Triantos, D N Samonakis, D Patch, A K Burroughs
Affiliations
Review

Infection, coagulation, and variceal bleeding in cirrhosis

U Thalheimer et al. Gut. 2005 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Damage to the intestinal barrier leads to bacterial translocation and endotoxaemia and thus to impairment of liver function and increase in portal pressure, possibly causing further damage to the gut: a vicious circle.
Figure 2
Figure 2
Endotoxaemia, bacterial translocation, and bacterial infection may be different expressions of the same process at different degrees of severity, and are associated with increasingly severe complications. NO, nitric oxide; TNF-α, tumour necrosis factor α.
Figure 3
Figure 3
Possible pathophysiological pathways through which bacterial infection can trigger variceal haemorrhage.
See this image and copyright information in PMC

Comment in

References

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    1. Goulis J, Armonis A, Patch D, et al. Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 1998;27:1207–12. - PubMed
    1. Hou MC, Lin HC, Liu TT, et al. Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial. Hepatology 2004;39:746–53. - PubMed

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